Temporal pressure enhanced topical drug delivery through micropore formation

Author:

Lio Daniel Chin Shiuan123ORCID,Chia Rui Ning3,Kwek Milton Sheng Yi23ORCID,Wiraja Christian1,Madden Leigh Edward34,Chang Hao1ORCID,Khadir S. Mohideen Abdul1ORCID,Wang Xiaomeng3567ORCID,Becker David L.34ORCID,Xu Chenjie1289ORCID

Affiliation:

1. School of Chemical and Biomedical Engineering, Nanyang Technological University, Nanyang Technological University, 62 Nanyang Drive, 637459, Singapore 637459, Singapore.

2. NTU Institute for Health Technologies, Interdisciplinary Graduate School, Nanyang Technological University, 50 Nanyang Drive, Singapore 637553, Singapore.

3. Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive Singapore 636921, Singapore.

4. Skin Research Institute of Singapore, Agency for Science, Technology and Research (A*STAR), 11 Mandalay Road, #17-01, Singapore 308232, Singapore.

5. Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, 61 Biopolis Dr, Singapore 138673, Singapore.

6. Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower Level 6, Singapore 169856, Singapore.

7. Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK.

8. National Dental Centre of Singapore, 5 Second Hospital Ave, Singapore 168938, Singapore.

9. Department of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, China.

Abstract

Temporal pressure improves transdermal drug delivery of molecules and nanoparticles via micropore formation.

Funder

City University of Hong Kong

Science and Engineering Research Council, Agency for Science, Technology and Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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