A CRISPR-Cas autocatalysis-driven feedback amplification network for supersensitive DNA diagnostics-Reference-Cited by-同舟云学术

A CRISPR-Cas autocatalysis-driven feedback amplification network for supersensitive DNA diagnostics

Published:2021-01-29 Issue:5 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Shi Kai¹^ORCID,Xie Shiyi¹,Tian Renyun²^ORCID,Wang Shuo¹,Lu Qin³,Gao Denghui⁴,Lei Chunyang¹^ORCID,Zhu Haizhen²,Nie Zhou¹^ORCID

Affiliation:

1. State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha 410082, P. R. China.

2. Institute of Pathogen Biology and Immunology of College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, China.

3. Hunan Research Center for Big Data Application in Genomics, Genetalks Inc., Changsha 410152, China

4. Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.

Abstract

A CRISPR-Cas–driven positive feedback circuit with exponential dynamic enables ultrasensitive detection of genomic DNA.

Funder

National Outstanding Youth Science Fund Project of National Natural Science Foundation of China

National Natural Science Foundation of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference40 articles.