Alternative polyadenylation is a determinant of oncogenic Ras function

Author:

Subramanian Aishwarya1ORCID,Hall Mathew2ORCID,Hou Huayun3ORCID,Mufteev Marat14,Yu Bin1,Yuki Kyoko E.3ORCID,Nishimura Haruka14ORCID,Sathaseevan Anson14ORCID,Lant Benjamin1,Zhai Beibei56,Ellis James14ORCID,Wilson Michael D.34ORCID,Daugaard Mads56ORCID,Derry W. Brent14ORCID

Affiliation:

1. Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.

2. Department of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.

3. Genetics and Genome Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.

4. Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.

5. Vancouver Prostate Centre, Vancouver, BC V6H 3Z6, Canada.

6. Department of Urologic Sciences, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.

Abstract

Shortening ends of mRNAs cooperate with oncogenes in development and cancer.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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