Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer-Reference-Cited by-同舟云学术

Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer

Published:2019-09-06 Issue:9 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Wang Lei¹²^ORCID,Zhang Lixiao¹²,Li Li¹²,Jiang Jingsheng¹²,Zheng Zhen³,Shang Jialin³,Wang Chengxiang³,Chen Weilin¹²,Bao Qichao¹²,Xu Xiaoli¹²^ORCID,Jiang Zhengyu¹²^ORCID,Zhang Jian³⁴^ORCID,You Qidong¹²^ORCID

Affiliation:

1. State Key Laboratory of Natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.

2. Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.

3. Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Medicinal Bioinformatics Center, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai, 200025, China.

4. School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.

Abstract

Directly disrupting the Hsp90-Cdc37 complex can selectively down-regulate kinase clients of Hsp90 and achieve cell cycle arrest.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Double First Class Innovation Team of China Pharmaceutical University

Natural Science Foundation of Jiangsu Province of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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