pH-dependent gating mechanism of the Helicobacter pylori urea channel revealed by cryo-EM-Reference-Cited by-同舟云学术

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pH-dependent gating mechanism of the Helicobacter pylori urea channel revealed by cryo-EM

Published:2019-03 Issue:3 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Cui Yanxiang¹²^ORCID,Zhou Kang¹²^ORCID,Strugatsky David³,Wen Yi⁴,Sachs George⁴,Zhou Z. Hong¹²^ORCID,Munson Keith⁴

Affiliation:

1. California NanoSystems Institute, University California Los Angeles, Los Angeles, CA 90095, USA.

2. Department of Microbiology, Immunology, & Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA.

3. Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA.

4. David Geffen School of Medicine, University of California Los Angeles and Greater West Los Angeles Health Care System, Los Angeles, CA 90095, USA.

Abstract

Comparison of closed and open channels defines pH-dependent gating mechanism and cooperativity between protomers in the hexamer.

Funder

National Institutes of Health

Health Services Research and Development

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference43 articles.

1. Global prevalence of Helicobacter pylori infection: Systematic review and meta-analysis;Hooi J. K. Y.;Gastroenterology,2017

2. High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor

3. Helicobacter pylori and gastric adenocarcinoma;Herrera V.;Clin. Microbiol. Infect.,2009

4. Helicobacter pylori eradication reduces the metachronous recurrence of gastric neoplasms by attenuating the precancerous process;Jung D. H.;J. Gastric Cancer,2015

5. Helicobacter pylori therapy for the prevention of metachronous gastric cancer;Choi I. J.;N. Engl. J. Med.,2018

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