High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging

Author:

Chen Junyu12ORCID,Sivan Unnikrishnan1ORCID,Tan Sin Lih1ORCID,Lippo Luciana1ORCID,De Angelis Jessica1,Labella Rossella1ORCID,Singh Amit13ORCID,Chatzis Alexandros1,Cheuk Stanley45ORCID,Medhghalchi Mino6,Gil Jesus78ORCID,Hollander Georg4ORCID,Marsden Brian D.69ORCID,Williams Richard6ORCID,Ramasamy Saravana K.78ORCID,Kusumbe Anjali P.1ORCID

Affiliation:

1. Tissue and Tumor Microenvironments Group, Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.

2. Department of Prosthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

3. Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, Heidelberg D-69120, Germany.

4. Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

5. Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden.

6. Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.

7. Institute of Clinical Sciences, Imperial College London, London W12 0NN, UK.

8. MRC London Institute of Medical Sciences, Imperial College London, London W12 0NN, UK.

9. Structural Genomics Consortium, NDM, University of Oxford, Oxford OX3 7DQ, UK.

Abstract

3D tissue imaging reveals maladaptations of blood vessels in organ aging, fibrosis, and arthritis.

Funder

Wellcome

H2020 European Research Council

Leukaemia UK

Medical Research Council

Cancer Research UK

John Fell Fund, University of Oxford

Office of the Royal Society

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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