Genomic gain of RRS1 promotes hepatocellular carcinoma through reducing the RPL11-MDM2-p53 signaling-Reference-Cited by-同舟云学术

Genomic gain of RRS1 promotes hepatocellular carcinoma through reducing the RPL11-MDM2-p53 signaling

Published:2021-08-27 Issue:35 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Cao Pengbo¹^ORCID,Yang Aiqing¹^ORCID,Li Peiyao¹^ORCID,Xia Xia¹,Han Yuqing¹,Zhou Guangming¹,Wang Rui¹^ORCID,Yang Fei¹,Li Yuanfeng¹^ORCID,Zhang Ying¹,Cui Ying²,Ji Hongzan³,Lu Lei⁴,He Fuchu⁵^ORCID,Zhou Gangqiao¹⁶⁷⁸^ORCID

Affiliation:

1. State Key Laboratory of Proteomics, National Center for Protein Sciences at Beijing, Beijing Institute of Radiation Medicine, Beijing, China.

2. Affiliated Cancer Hospital of Guangxi Medical University, Nanning City, China.

3. Department of Gastroenterology and Hepatology, Jinling Hospital, Clinical School of Nanjing University, Nanjing City, China.

4. Department of Surgical Oncology, Jingdu Hospital, Nanjing City, China.

5. State Key Laboratory of Proteomics, National Center for Protein Sciences at Beijing, Beijing Institute of Lifeomics, Beijing, China.

6. Collaborative Innovation Center for Personalized Cancer Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing City, China.

7. Anhui Medical University, Hefei City, China.

8. Hebei University, Shijiazhuang City, China.

Abstract

RRS1 is a chromosome 8q oncogene that couples ribosome biogenesis to RPL11-MDM2-p53 signaling in hepatocellular carcinoma.

Funder

National Key Research and Development Program of China Stem Cell and Translational Research

Major Research Plan of the National Natural Science Foundation of China

State Key Infection Disease Project of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary