Gene losses in the common vampire bat illuminate molecular adaptations to blood feeding-Reference-Cited by-同舟云学术

Gene losses in the common vampire bat illuminate molecular adaptations to blood feeding

Published:2022-03-25 Issue:12 Volume:8 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Blumer Moritz¹²³⁴^ORCID,Brown Tom¹^ORCID,Freitas Mariella Bontempo⁵^ORCID,Destro Ana Luiza⁵^ORCID,Oliveira Juraci A.⁶^ORCID,Morales Ariadna E.⁴⁷⁸^ORCID,Schell Tilman⁷⁸,Greve Carola⁷⁸^ORCID,Pippel Martin¹^ORCID,Jebb David¹²³,Hecker Nikolai¹²³,Ahmed Alexis-Walid⁴⁷⁸,Kirilenko Bogdan M.⁴⁷⁸^ORCID,Foote Maddy⁹^ORCID,Janke Axel⁷¹⁰^ORCID,Lim Burton K.¹¹^ORCID,Hiller Michael¹²³⁴⁷^ORCID

Affiliation:

1. Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.

2. Max Planck Institute for the Physics of Complex Systems, 01187 Dresden, Germany.

3. Center for Systems Biology Dresden, 01307 Dresden, Germany.

4. Goethe University, Faculty of Biosciences, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany.

5. Department of Animal Biology, Federal University of Viçosa, Viçosa, Brazil.

6. Department of General Biology, Federal University of Viçosa, Viçosa, Brazil.

7. LOEWE Centre for Translational Biodiversity Genomics, Senckenberganlage 25, 60325 Frankfurt, Germany.

8. Senckenberg Research Institute, Senckenberganlage 25, 60325 Frankfurt, Germany.

9. Native Bat Conservation Program, Toronto Zoo, 361A Old Finch Avenue, Toronto, Ontario M1B 5K7, Canada.

10. Senckenberg Biodiversity and Climate Research Centre, Senckenberganlage 25, 60325 Frankfurt am Main, Germany.

11. Department of Natural History, Royal Ontario Museum, 100 Queen’s Park, Toronto, Ontario M5S 2C6, Canada.

Abstract

Vampire bats are the only mammals that feed exclusively on blood. To uncover genomic changes associated with this dietary adaptation, we generated a haplotype-resolved genome of the common vampire bat and screened 27 bat species for genes that were specifically lost in the vampire bat lineage. We found previously unknown gene losses that relate to reduced insulin secretion ( FFAR1 and SLC30A8 ), limited glycogen stores ( PPP1R3E ), and a unique gastric physiology ( CTSE ). Other gene losses likely reflect the biased nutrient composition ( ERN2 and CTRL ) and distinct pathogen diversity of blood ( RNASE7 ) and predict the complete lack of cone-based vision in these strictly nocturnal bats ( PDE6H and PDE6C ). Notably, REP15 loss likely helped vampire bats adapt to high dietary iron levels by enhancing iron excretion, and the loss of CYP39A1 could have contributed to their exceptional cognitive abilities. These findings enhance our understanding of vampire bat biology and the genomic underpinnings of adaptations to blood feeding.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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