Discriminative T cell recognition of cross-reactive islet-antigens is associated with HLA-DQ8 transdimer–mediated autoimmune diabetes-Reference-Cited by-同舟云学术

Discriminative T cell recognition of cross-reactive islet-antigens is associated with HLA-DQ8 transdimer–mediated autoimmune diabetes

Published:2019-08-02 Issue:8 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Chow I-Ting¹^ORCID,Gates Theresa J.¹,Papadopoulos George K.²^ORCID,Moustakas Antonis K.³,Kolawole Elizabeth M.⁴^ORCID,Notturno Richard J.¹^ORCID,McGinty John W.¹,Torres-Chinn Nadia¹,James Eddie A.¹^ORCID,Greenbaum Carla¹,Nepom Gerald T.¹⁵^ORCID,Evavold Brian D.⁴^ORCID,Kwok William W.¹⁶^ORCID

Affiliation:

1. Benaroya Research Institute at Virginia Mason, 1201 9th Ave., Seattle, WA 98101, USA.

2. Laboratory of Biophysics, Biochemistry, Bioprocessing and Bioproducts, Faculty of Agricultural Technology, Technological Educational Institute of Epirus, GR47100 Arta, Greece.

3. Department of Food Technology, Ionian University, GR28100 Argostoli, Cephallonia, Greece.

4. Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.

5. Department of Immunology, University of Washington, Seattle, WA 98195, USA.

6. Department of Medicine, University of Washington, Seattle, WA 98195, USA.

Abstract

A functional epistatic interaction between susceptible HLAs provides a molecular basis for the contribution of HLA-DQ8 transdimer.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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