Three-dimensional chromatin interactions remain stable upon CAG/CTG repeat expansion

Author:

Ruiz Buendía Gustavo A.1ORCID,Leleu Marion23,Marzetta Flavia3ORCID,Vanzan Ludovica4ORCID,Tan Jennifer Y.5ORCID,Ythier Victor4ORCID,Randall Emma L.6ORCID,Marques Ana C.5ORCID,Baubec Tuncay7ORCID,Murr Rabih48ORCID,Xenarios Ioannis1ORCID,Dion Vincent6ORCID

Affiliation:

1. Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, 1015 Lausanne, Switzerland.

2. School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.

3. Vital-IT Group, Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.

4. Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland.

5. Department of Computational Biology, Faculty of Biology and Medicine, University of Lausanne, 1015 Lausanne, Switzerland.

6. UK Dementia Research Institute at Cardiff University at Cardiff University, Hadyn Ellis Building, Maindy Road, CF24 4HQ Cardiff, UK.

7. Department of Molecular Mechanisms of Disease, University of Zurich, 8057 Zurich, Switzerland.

8. Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, 1211 Geneva, Switzerland.

Abstract

Unexpectedly, the molecular pathogenesis of expanded CAG/CTG diseases does not include changes in 3D chromatin conformation.

Funder

Swiss National Science Foundation

SystemsX.ch

UK DRI

NCCR in RNA and Disease

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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