Poststroke delivery of MANF promotes functional recovery in rats

Author:

Mätlik Kert1ORCID,Anttila Jenni E.1,Kuan-Yin Tseng1,Smolander Olli-Pekka1ORCID,Pakarinen Emmi1,Lehtonen Leevi1ORCID,Abo-Ramadan Usama1ORCID,Lindholm Päivi1,Zheng Congjun1,Harvey Brandon2ORCID,Arumäe Urmas13ORCID,Lindahl Maria1,Airavaara Mikko1ORCID

Affiliation:

1. Program in Developmental Biology, Institute of Biotechnology, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland.

2. National Institute on Drug Abuse, 251 Bayview Boulevard, Baltimore, MD 21224, USA.

3. School of Science, Department of Chemistry and Biotechnology, Division of Gene Technology, Tallinn University of Technology, Akadeemia tee 15, Tallinn 12618, Estonia.

Abstract

Delayed delivery of MANF to rat brain after ischemic stroke promotes functional recovery and recruits phagocytic immune cells.

Funder

Juvenile Diabetes Research Foundation

Estonian Research Council

European Social Fund

Academy of Finland

EU FP7 GLORIA

Ella and Georg Ehrnrooth Foundation

Finnish Graduate School of Neuroscience

Sigrid Jusélius Foundation

Finnish Funding Agency for Technology and Innovation

Alfred Kordelin Foundation

Orion Research Foundation

Päivikki and Sakari Sohlberg Foundation

The Intramural Research Program at the National Institute on Drug Abuse, National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference30 articles.

1. Acute ischemic stroke;van der Worp H. B.;N. Engl. J. Med.,2007

2. Persisting consequences of stroke measured by the Stroke Impact Scale;Lai S. M.;Stroke,2002

3. Heart disease and stroke statistics—2016 update: A report from the american heart association;Writing Group Members;Circulation,2016

4. Rehabilitation after stroke;Dobkin B. H.;N. Engl. J. Med.,2005

5. AAV-mediated targeting of gene expression to the peri-infarct region in rat cortical stroke model;Mätlik K.;J. Neurosci. Methods,2014

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