A nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stems-Reference-Cited by-同舟云学术

A nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stems

Published:2020-07-31 Issue:31 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Cai Yiming¹^ORCID,Usher Ben²^ORCID,Gutierrez Claude³^ORCID,Tolcan Anastasia⁴,Mansour Moise¹^ORCID,Fineran Peter C.⁵⁶⁷^ORCID,Condon Ciarán⁴^ORCID,Neyrolles Olivier³^ORCID,Genevaux Pierre¹^ORCID,Blower Tim R.²^ORCID

Affiliation:

1. Laboratoire de Microbiologie et Génétique Moléculaires, Centre de Biologie Intégrative, Université de Toulouse, CNRS, UPS, 118 route de Narbonne, 31400 Toulouse, France.

2. Department of Biosciences, Durham University, South Road, Durham DH1 3LE, UK.

3. Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, 205 route de Narbonne, 31400 Toulouse, France.

4. UMR8261 (CNRS, Université de Paris), Institut de Biologie Physico-Chimique, 13 rue Pierre et Marie Curie, 75005 Paris, France.

5. Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin 9054, New Zealand.

6. Genetics Otago, University of Otago, PO Box 56, Dunedin 9054, New Zealand.

7. Bio-protection Research Centre, University of Otago, PO Box 56, Dunedin 9054, New Zealand.

Abstract

The human pathogen Mycobacterium tuberculosis produces a toxin that can stall bacterial growth by blocking the activity of tRNAs.

Funder

University of Otago

Academy of Medical Sciences

Agence Nationale de la Recherche

Fondation pour la Recherche Médicale

China Scholarship Council

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference56 articles.

1. Toxin-Antitoxin Systems Are Important for Niche-Specific Colonization and Stress Resistance of Uropathogenic Escherichia coli

2. Internalization of Salmonella by Macrophages Induces Formation of Nonreplicating Persisters

3. Toxin-antitoxin systems in bacterial growth arrest and persistence

4. The phage abortive infection system, ToxIN, functions as a protein–RNA toxin–antitoxin pair

5. Exclusion of T4 phage by the hok/sok killer locus from plasmid R1

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