Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types

Author:

Saez-Atienzar Sara1ORCID,Bandres-Ciga Sara23,Langston Rebekah G.4ORCID,Kim Jonggeol J.2,Choi Shing Wan5,Reynolds Regina H.678ORCID,Abramzon Yevgeniya19,Dewan Ramita1ORCID,Ahmed Sarah10ORCID,Landers John E.11ORCID,Chia Ruth1ORCID,Ryten Mina78ORCID,Cookson Mark R.4ORCID,Nalls Michael A.212,Chiò Adriano1314ORCID,Traynor Bryan J.115, ,

Affiliation:

1. Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

2. Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

3. Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain.

4. Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

5. Department of Genetics and Genomic Sciences, Icahn School of Medicine, Mount Sinai, 1 Gustave L. Levy Pl, New York, NY 10029, USA.

6. Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.

7. NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK.

8. Great Ormond Street Institute of Child Health, Genetics and Genomic Medicine, University College London, London, UK.

9. Sobell Department of Motor Neuroscience and Movement Disorders, University College London, Institute of Neurology, London, UK.

10. Neurodegenerative Diseases Research Unit, Laboratory of Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

11. Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

12. Data Tecnica International, Glen Echo, MD 20812, USA.

13. ‘Rita Levi Montalcini’ Department of Neuroscience, University of Turin, Turin, Italy.

14. Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy.

15. Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA.

Abstract

Massive genetic analysis identifies critical pathways and cell types involved in pathogenesis of amyotrophic lateral sclerosis.

Funder

National Institute on Aging

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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