Lipidomics and RNA sequencing reveal a novel subpopulation of nanovesicle within extracellular matrix biomaterials

Author:

Hussey George S.12ORCID,Pineda Molina Catalina12ORCID,Cramer Madeline C.13ORCID,Tyurina Yulia Y.4,Tyurin Vladimir A.4,Lee Yoojin C.13ORCID,El-Mossier Salma O.1,Murdock Mark H.1,Timashev Peter S.5ORCID,Kagan Valerian E.456,Badylak Stephen F.123ORCID

Affiliation:

1. McGowan Institute for Regenerative Medicine, University of Pittsburgh, 450 Technology Drive, Suite 300, Pittsburgh, PA 15219-3110, USA.

2. Department of Surgery, School of Medicine, University of Pittsburgh, University of Pittsburgh Medical Center Presbyterian Hospital, 200 Lothrop Street, Pittsburgh, PA 15213, USA.

3. Department of Bioengineering, University of Pittsburgh, 3700 O’Hara Street, Pittsburgh, PA 15261, USA.

4. Center for Free Radical and Antioxidant Health and Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA.

5. Laboratory of Navigational Redox Lipidomics, IM Sechenov Moscow State Medical University, Moscow, Russia.

6. Departments of Pharmacology and Chemical Biology, Chemistry, Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Abstract

Matrix-bound nanovesicles (MBVs) are a novel subclass of extracellular vesicles.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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