Gene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in high-fat diet

Gene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in high-fat diet–induced obesity

Published:2020-05-08 Issue:19 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Tang Ruhang¹²³^ORCID,Harasymowicz Natalia S.¹²³,Wu Chia-Lung¹²³^ORCID,Collins Kelsey H.¹²³^ORCID,Choi Yun-Rak¹²³⁴^ORCID,Oswald Sara J.¹²³^ORCID,Guilak Farshid¹²³^ORCID

Affiliation:

1. Department of Orthopaedic Surgery, Washington University, St. Louis, MO, USA.

2. Shriners Hospitals for Children, St. Louis, MO, USA.

3. Center of Regenerative Medicine, Washington University, St. Louis, MO, USA.

4. Department of Orthopaedic Surgery, Yonsei University College of Medicine, Seoul, South Korea.

Abstract

Follistatin gene therapy prevents obesity, metabolic disease, and post-traumatic osteoarthritis.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference46 articles.

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4. A High-Fat High-Sucrose Diet Rapidly Alters Muscle Integrity, Inflammation and Gut Microbiota in Male Rats

5. Obesity, Metabolic Syndrome, and Musculoskeletal Disease: Common Inflammatory Pathways Suggest a Central Role for Loss of Muscle Integrity

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