Plasma cells shape the mesenchymal identity of ovarian cancers through transfer of exosome-derived microRNAs

Author:

Yang Zhengnan12ORCID,Wang Wei3ORCID,Zhao Linjie4ORCID,Wang Xin5ORCID,Gimple Ryan C.4ORCID,Xu Lian6ORCID,Wang Yuan2ORCID,Rich Jeremy N.4ORCID,Zhou Shengtao1ORCID

Affiliation:

1. Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE and State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, P. R. China.

2. Department of Neurology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and National Collaborative Innovation Center, Chengdu 610041, P. R. China.

3. Department of Gynecology, Huzhou Maternity & Child Health Care Hospital, Huzhou, P. R. China.

4. Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA

5. Department of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong, P. R. China.

6. Department of Pathology, West China Second University Hospital, Sichuan University, Chengdu, P. R. China.

Abstract

Plasma cells shape the mesenchymal identity of ovarian cancers through exosome-mediated miR-330-3p/JAM2 axis.

Funder

National Institutes of Health

National Natural Science Foundation of China

Graduate Student’s Research and Innovation Fund of Sichuan University

National Key Research and Development Program of China Stem Cell and Translational Research

Direct Scientific Research Grants from West China Second Hospital, Sichuan University

Sichuan Science-Technology International Cooperation Project

Research Grants Council of the Hong Kong Special Administrative Region, China

NIH grants

NIH Grant

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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