Epithelial-type systemic breast carcinoma cells with a restricted mesenchymal transition are a major source of metastasis

Author:

Liu Xiao1,Li Junjian2,Cadilha Bruno Loureiro3ORCID,Markota Anamarija3,Voigt Cornelia3,Huang Zhe1,Lin Peter P.4,Wang Daisy D.4,Dai Juncheng5,Kranz Gisela1,Krandick Anna1,Libl Darko1,Zitzelsberger Horst678,Zagorski Isabella7,Braselmann Herbert7,Pan Min1,Zhu Sibo9,Huang Yuanchi1,Niedermeyer Sebastian1,Reichel Christoph A.1,Uhl Bernd1,Briukhovetska Daria3,Suárez Javier3,Kobold Sebastian3ORCID,Gires Olivier16ORCID,Wang Hongxia2

Affiliation:

1. Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, Ludwig-Maximilians University of Munich, Marchioninistr. 15, 81377 Munich, Germany.

2. Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.

3. Center of Integrated Protein Science Munich and Division of Clinical Pharmacology, Department of Medicine IV, Klinikum der Ludwig-Maximilians-Universität München, Member of the German Center for Lung Research, Lindwurmstrasse 2a, 80337 Munich, Germany.

4. Cytelligen, San Diego, CA 92121, USA.

5. Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China.

6. Clinical Cooperation Group Personalized Radiotherapy of Head and Neck Tumors, Helmholtz Zentrum München, Neuherberg, Germany.

7. Research Unit Radiation Cytogenetics, Helmholtz Zentrum München, Neuherberg, Germany.

8. Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany.

9. State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, China.

Abstract

Association of epithelial-mesenchymal transition with the metastatic potential of disseminated cells in breast cancer was studied.

Funder

Deutsche Forschungsgemeinschaft

ERC Starting Grant

Shanghai Science and Technology Innovation Action Plan

Elite Network of Bavaria

Marie-Sklodowska-Curie H2020 program European Union

China National Natural Science Funds

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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