Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication-Reference-Cited by-同舟云学术

Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication

Published:2020-05-29 Issue:22 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Boeckemeier L.¹^ORCID,Kraehenbuehl R.¹²^ORCID,Keszthelyi A.¹^ORCID,Gasasira M. U.¹,Vernon E. G.¹,Beardmore R.¹,Vågbø C. B.³,Chaplin D.²^ORCID,Gollins S.¹,Krokan H. E.³,Lambert S. A. E.⁴^ORCID,Paizs B.²^ORCID,Hartsuiker E.¹^ORCID

Affiliation:

1. North West Cancer Research Institute, School of Medical Sciences, Bangor University, Bangor, Gwynedd LL57 2UW, UK.

2. Centre for Environmental Biotechnology, School of Natural Sciences, Bangor University, Bangor, Gwynedd LL57 2UW, UK.

3. Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway.

4. Institut Curie, Paris-Saclay University, UMR3348, F-91450 Orsay, France.

Abstract

Mre11 exonuclease activity removes gemcitabine from the nascent strand during DNA replication.

Funder

Cancer Research UK

North West Cancer Research Fund

ERDF

Life Sciences Research Network Wales

Charity 8Q03 Cancer Research Fund

Hannah Mary Michael Fund

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference59 articles.

1. Replication-Coupled DNA Repair

2. Homologous recombination and the repair of DNA double-strand breaks

3. Role of the Mre11 Complex in Preserving Genome Integrity

4. Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1

5. Physiological protein blocks direct the Mre11–Rad50–Xrs2 and Sae2 nuclease complex to initiate DNA end resection

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