LKB1 specifies neural crest cell fates through pyruvate-alanine cycling-Reference-Cited by-同舟云学术

LKB1 specifies neural crest cell fates through pyruvate-alanine cycling

Published:2019-07-05 Issue:7 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Radu Anca G.¹^ORCID,Torch Sakina¹^ORCID,Fauvelle Florence²³,Pernet-Gallay Karin²,Lucas Anthony¹,Blervaque Renaud¹,Delmas Véronique⁴,Schlattner Uwe⁵⁶,Lafanechère Laurence¹^ORCID,Hainaut Pierre¹,Tricaud Nicolas⁷,Pingault Véronique⁸^ORCID,Bondurand Nadège⁸,Bardeesy Nabeel⁹¹⁰¹¹^ORCID,Larue Lionel⁴^ORCID,Thibert Chantal¹^ORCID,Billaud Marc¹¹²^ORCID

Affiliation:

1. Institute for Advanced Biosciences, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, 38000 Grenoble, France.

2. Univ. Grenoble Alpes, INSERM, U1216, Grenoble Institute of Neurosciences GIN, 38000 Grenoble, France.

3. Univ. Grenoble Alpes, INSERM, US17, MRI facility IRMaGe, 38000 Grenoble, France.

4. Institut Curie, Normal and Pathological Development of Melanocytes, CNRS UMR3347; INSERM U1021; Equipe Labellisée–Ligue Nationale Contre le Cancer, Orsay, France.

5. Laboratory of Fundamental and Applied Bioenergetics, Univ Grenoble Alpes, 38185 Grenoble, France.

6. INSERM U1055, 38041 Grenoble France.

7. INSERM U1051, Institut des Neurosciences de Montpellier (INM), Université de Montpellier, Montpellier, France.

8. INSERM U1163, Institut Imagine, Paris, France.

9. Cancer Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.

10. Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.

11. Department of Medicine, Harvard Medical School, Boston, MA 02114, USA.

12. “Clinical and experimental model of lymphomagenesis” Univ Lyon, Université Claude Bernard Lyon1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de recherche en cancérologie de Lyon, Lyon France.

Abstract

Glial specification of neural crest cells requires the tumor suppressor LKB1-mediated action on alanine biosynthesis.

Funder

Association pour la Recherche sur le Cancer

Ligue Contre le Cancer

Institut National Du Cancer

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference81 articles.

1. N. Le Douarin C. Kalcheim The neural crest in Developmental and Cell Biology Series (Cambridge Univ. Press ed. 2 1999).