Network-based atrophy modeling in the common epilepsies: A worldwide ENIGMA study

Author:

Larivière Sara1ORCID,Rodríguez-Cruces Raúl1,Royer Jessica1,Caligiuri Maria Eugenia2,Gambardella Antonio23,Concha Luis4,Keller Simon S.56,Cendes Fernando7,Yasuda Clarissa7ORCID,Bonilha Leonardo8,Gleichgerrcht Ezequiel8,Focke Niels K.9,Domin Martin10,von Podewills Felix11,Langner Soenke12,Rummel Christian13,Wiest Roland13,Martin Pascal14,Kotikalapudi Raviteja14,O’Brien Terence J.1516,Sinclair Benjamin1516,Vivash Lucy1516,Desmond Patricia M.16,Alhusaini Saud1718,Doherty Colin P.1920,Cavalleri Gianpiero L.1720ORCID,Delanty Norman1720,Kälviäinen Reetta2122,Jackson Graeme D.23,Kowalczyk Magdalena23,Mascalchi Mario24,Semmelroch Mira23,Thomas Rhys H.25,Soltanian-Zadeh Hamid2627,Davoodi-Bojd Esmaeil28,Zhang Junsong29,Lenge Matteo3031,Guerrini Renzo30,Bartolini Emanuele32,Hamandi Khalid3334,Foley Sonya34,Weber Bernd35,Depondt Chantal36ORCID,Absil Julie37,Carr Sarah J. A.38,Abela Eugenio38,Richardson Mark P.38,Devinsky Orrin39,Severino Mariasavina40,Striano Pasquale40,Tortora Domenico40,Hatton Sean N.41,Vos Sjoerd B.424344,Duncan John S.4243,Whelan Christopher D.17,Thompson Paul M.45ORCID,Sisodiya Sanjay M.4243,Bernasconi Andrea46,Labate Angelo23,McDonald Carrie R.47,Bernasconi Neda46,Bernhardt Boris C.1ORCID

Affiliation:

1. Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.

2. Neuroscience Research Center, University Magna Græcia, Catanzaro, CZ, Italy.

3. Institute of Neurology, University Magna Græcia, Catanzaro, CZ, Italy.

4. Institute of Neurobiology, Universidad Nacional Autónoma de México, Querétaro, México.

5. Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.

6. Walton Centre NHS Foundation Trust, Liverpool, UK.

7. Department of Neurology, University of Campinas–UNICAMP, Campinas, São Paulo, Brazil.

8. Department of Neurology, Medical University of South Carolina, Charleston, SC, USA.

9. Department of Clinical Neurophysiology, University of Medicine Göttingen, Göttingen, Germany.

10. Institute of Diagnostic Radiology and Neuroradiology, Functional Imaging Unit, University Medicine Greifswald, Greifswald, Germany.

11. Department of Neurology, University Medicine Greifswald, Greifswald, Germany.

12. Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.

13. Support Center for Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Bern, Switzerland.

14. Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

15. Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.

16. Departments of Medicine and Radiology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.

17. Department of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.

18. Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.

19. Department of Neurology, St. James’ Hospital, Dublin, Ireland.

20. FutureNeuro SFI Research Centre, Dublin, Ireland.

21. Epilepsy Center, Neuro Center, Kuopio University Hospital, European Reference Network for Rare and Complex Epilepsies EpiCARE, Kuopio, Finland.

22. Faculty of Health Sciences, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.

23. Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria 3010, Australia.

24. Neuroradiology Research Program, Meyer Children Hospital of Florence, University of Florence, Florence, Italy.

25. Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.

26. Control and Intelligent Processing Center of Excellence (CIPCE), School of Electrical and Computer Engineering, University of Tehran, Tehran, Iran.

27. Departments of Research Administration and Radiology, Henry Ford Health System, Detroit, MI, USA.

28. Department of Neurology, Henry Ford Health System, Detroit, MI, USA.

29. Cognitive Science Department, Xiamen University, Xiamen, China.

30. Child Neurology Unit and Laboratories, Neuroscience Department, Children’s Hospital A. Meyer—University of Florence, Italy.

31. Functional and Epilepsy Neurosurgery Unit, Neurosurgery Department, Children’s Hospital A. Meyer—University of Florence, Italy.

32. USL Centro Toscana, Neurology Unit, Nuovo Ospedale Santo Stefano, Prato, Italy.

33. Cardiff University Brain Research Imaging Centre (CUBRIC), College of Biomedical Sciences, Cardiff University, Cardiff, UK.

34. Welsh Epilepsy Unit, Department of Neurology, University Hospital of Wales, Cardiff, UK.

35. Institute of Experimental Epileptology and Cognition Research, University Hospital Bonn, Bonn, Germany.

36. Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.

37. Department of Radiology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.

38. Division of Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK.

39. Department of Neurology, NYU Grossman School of Medicine, New York, NY, USA.

40. IRCCS Istituto Giannina Gaslini, Genova, Italy.

41. Department of Neurosciences, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, USA.

42. Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK.

43. Chalfont Centre for Epilepsy, Bucks, UK.

44. Centre for Medical Image Computing, University College London, London, UK.

45. Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, USC Keck School of Medicine, Los Angeles, CA, USA.

46. Neuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.

47. Department of Psychiatry, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, USA.

Abstract

Brain atrophy in human epilepsy syndromes is explainable by network architecture and strongest in hub regions.

Funder

National Institutes of Health

Canadian Institutes of Health Research

Natural Sciences and Engineering Research Council of Canada

Fundacao de Amparo a Pesquisa do Estado de Sao Paulo

Sick Kids Foundation

UK Medical Research Council

National Institutes of Health Big Data to Knowledge

ENIGMA World Aging Center

ENIGMA Sex Differences Initiative

National Health and Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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