Single-cell damagenome profiling unveils vulnerable genes and functional pathways in human genome toward DNA damage-Reference-Cited by-同舟云学术

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Single-cell damagenome profiling unveils vulnerable genes and functional pathways in human genome toward DNA damage

Published:2021-07-02 Issue:27 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Zhu Qiangyuan¹^ORCID,Niu Yichi¹^ORCID,Gundry Michael¹^ORCID,Zong Chenghang¹²³^ORCID

Affiliation:

1. Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

2. Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

3. McNair Medical Institute, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

Abstract

A new single-cell whole-genome amplification method allows the genome-wide characterization of DNA damage and gene vulnerability.

Funder

NIH Office of the Director

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference67 articles.

1. Endogenous DNA damage in humans: a review of quantitative data

2. Measurement of oxidatively induced DNA damage and its repair, by mass spectrometric techniques

3. Oxidants, antioxidants, and the degenerative diseases of aging.

4. Involvement of oxidatively damaged DNA and repair in cancer development and aging;Tudek B.;Am. J. Transl. Res.,2010

5. Epigenome Maintenance in Response to DNA Damage

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