Endogenous retroviruses drive KRAB zinc-finger protein family expression for tumor suppression-Reference-Cited by-同舟云学术

Endogenous retroviruses drive KRAB zinc-finger protein family expression for tumor suppression

Published:2020-10-23 Issue:43 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Ito Jumpei¹^ORCID,Kimura Izumi¹,Soper Andrew²^ORCID,Coudray Alexandre³,Koyanagi Yoshio²,Nakaoka Hirofumi⁴,Inoue Ituro⁴,Turelli Priscilla³^ORCID,Trono Didier³^ORCID,Sato Kei¹⁵^ORCID

Affiliation:

1. Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 1088639, Japan.

2. Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 6068507, Japan.

3. School of Life Sciences, Ecole Polytechnique Federale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

4. Division of Human Genetics, National Institute of Genetics, Mishima 4118540, Japan.

5. CREST, Japan Science and Technology Agency, Kawaguchi, Saitama 3320012, Japan.

Abstract

The derepression of HERVs in tumors leads to the up-regulation of hundreds of KZFPs, which are potential tumor suppressors.

Funder

Japan Agency for Medical Research and Development

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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