Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites-Reference-Cited by-同舟云学术

Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites

Published:2023-02-24 Issue:8 Volume:9 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Song Joseph W.¹²³^ORCID,Ryu Hanjun⁴^ORCID,Bai Wubin⁵^ORCID,Xie Zhaoqian⁶⁷^ORCID,Vázquez-Guardado Abraham²^ORCID,Nandoliya Khizar²^ORCID,Avila Raudel⁸,Lee Geumbee²^ORCID,Song Zhen⁶^ORCID,Kim Jihye²,Lee Min-Kyu²^ORCID,Liu Yugang³^ORCID,Kim Mirae³,Wang Huifeng³,Wu Yixin²^ORCID,Yoon Hong-Joon⁹^ORCID,Kwak Sung Soo¹⁰^ORCID,Shin Jaeho²^ORCID,Kwon Kyeongha¹¹,Lu Wei²^ORCID,Chen Xuexian¹²,Huang Yonggang²⁸¹³¹⁴^ORCID,Ameer Guillermo A.¹²³¹⁵¹⁶^ORCID,Rogers John A.¹²³⁸¹⁴^ORCID

Affiliation:

1. Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.

2. Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.

3. Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.

4. Department of Advanced Materials Engineering, Chung-Ang University, Anseong, Korea.

5. Department of Applied Physical Sciences, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

6. State Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian 116023, P. R. China.

7. DUT-BSU Joint Institute, Dalian University of Technology, Dalian 116024, China.

8. Department of Mechanical Engineering, Northwestern University, Evanston, IL, USA.

9. Department of Electronic Engineering, Gachon University, Seongnam 13120, Korea.

10. Center for Bionics of Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, Korea.

11. Department of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea.

12. Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871 China.

13. Departments of Civil and Environmental Engineering, Northwestern University, Evanston, IL, USA.

14. Department of Materials Science and Engineering, Northwestern University, Evanston, IL, USA.

15. Simpson Querrey Institute for Bionanotechnology, Evanston, IL, USA.

16. Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, USA.

Abstract

Chronic wounds, particularly those associated with diabetes mellitus, represent a growing threat to public health, with additional notable economic impacts. Inflammation associated with these wounds leads to abnormalities in endogenous electrical signals that impede the migration of keratinocytes needed to support the healing process. This observation motivates the treatment of chronic wounds with electrical stimulation therapy, but practical engineering challenges, difficulties in removing stimulation hardware from the wound site, and absence of means to monitor the healing process create barriers to widespread clinical use. Here, we demonstrate a miniaturized wireless, battery-free bioresorbable electrotherapy system that overcomes these challenges. Studies based on a splinted diabetic mouse wound model confirm the efficacy for accelerated wound closure by guiding epithelial migration, modulating inflammation, and promoting vasculogenesis. Changes in the impedance provide means for tracking the healing process. The results demonstrate a simple and effective platform for wound site electrotherapy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

https://www.science.org/doi/pdf/10.1126/sciadv.ade4687

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