Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites

Author:

Song Joseph W.123ORCID,Ryu Hanjun4ORCID,Bai Wubin5ORCID,Xie Zhaoqian67ORCID,Vázquez-Guardado Abraham2ORCID,Nandoliya Khizar2ORCID,Avila Raudel8,Lee Geumbee2ORCID,Song Zhen6ORCID,Kim Jihye2,Lee Min-Kyu2ORCID,Liu Yugang3ORCID,Kim Mirae3,Wang Huifeng3,Wu Yixin2ORCID,Yoon Hong-Joon9ORCID,Kwak Sung Soo10ORCID,Shin Jaeho2ORCID,Kwon Kyeongha11,Lu Wei2ORCID,Chen Xuexian12,Huang Yonggang281314ORCID,Ameer Guillermo A.1231516ORCID,Rogers John A.123814ORCID

Affiliation:

1. Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.

2. Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.

3. Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.

4. Department of Advanced Materials Engineering, Chung-Ang University, Anseong, Korea.

5. Department of Applied Physical Sciences, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

6. State Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian 116023, P. R. China.

7. DUT-BSU Joint Institute, Dalian University of Technology, Dalian 116024, China.

8. Department of Mechanical Engineering, Northwestern University, Evanston, IL, USA.

9. Department of Electronic Engineering, Gachon University, Seongnam 13120, Korea.

10. Center for Bionics of Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, Korea.

11. Department of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea.

12. Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871 China.

13. Departments of Civil and Environmental Engineering, Northwestern University, Evanston, IL, USA.

14. Department of Materials Science and Engineering, Northwestern University, Evanston, IL, USA.

15. Simpson Querrey Institute for Bionanotechnology, Evanston, IL, USA.

16. Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, USA.

Abstract

Chronic wounds, particularly those associated with diabetes mellitus, represent a growing threat to public health, with additional notable economic impacts. Inflammation associated with these wounds leads to abnormalities in endogenous electrical signals that impede the migration of keratinocytes needed to support the healing process. This observation motivates the treatment of chronic wounds with electrical stimulation therapy, but practical engineering challenges, difficulties in removing stimulation hardware from the wound site, and absence of means to monitor the healing process create barriers to widespread clinical use. Here, we demonstrate a miniaturized wireless, battery-free bioresorbable electrotherapy system that overcomes these challenges. Studies based on a splinted diabetic mouse wound model confirm the efficacy for accelerated wound closure by guiding epithelial migration, modulating inflammation, and promoting vasculogenesis. Changes in the impedance provide means for tracking the healing process. The results demonstrate a simple and effective platform for wound site electrotherapy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference55 articles.

1. Economic Costs of Diabetes in the U.S. in 2017

2. Incidence and risk factors of diabetic foot ulcer: A population-based diabetic foot cohort (ADFC study)—Two-year follow-up study;Yazdanpanah L.;Int. J. Endocrinol.

3. Amputation and Mortality in New-Onset Diabetic Foot Ulcers Stratified by Etiology

4. Challenges in the Treatment of Chronic Wounds

5. Factors Affecting Wound Healing

Cited by 61 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3