Lactate and IL6 define separable paths of inflammatory metabolic adaptation-Reference-Cited by-同舟云学术

Lactate and IL6 define separable paths of inflammatory metabolic adaptation

Published:2021-06-25 Issue:26 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Dichtl Stefanie¹^ORCID,Lindenthal Laura¹,Zeitler Leonie¹,Behnke Kristina²^ORCID,Schlösser Daniela³,Strobl Birgit⁴^ORCID,Scheller Jürgen²,El Kasmi Karim C.³,Murray Peter J.¹^ORCID

Affiliation:

1. Max Planck Institute of Biochemistry, Martinsried, Germany.

2. Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.

3. Boehringer Ingelheim Pharma GmbH & Co KG, 88397 Biberach, Germany.

4. Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria.

Abstract

Inflammation induces macrophage histone lactylation uncoupled from arginine metabolism or M2 polarization.

Funder

Alexander von Humboldt-Stiftung

Deutsche Forschungsgemeinschaft

Max Planck Gesellschaft

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference38 articles.

1. Immunometabolism governs dendritic cell and macrophage function

2. Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells

3. Metabolic regulation of gene expression by histone lactylation

4. Modification of Proteins by Metabolites in Immunity

5. TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation

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