Guide-free Cas9 from pathogenic Campylobacter jejuni bacteria causes severe damage to DNA-Reference-Cited by-同舟云学术

Guide-free Cas9 from pathogenic Campylobacter jejuni bacteria causes severe damage to DNA

Published:2020-06-19 Issue:25 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Saha Chinmoy¹^ORCID,Mohanraju Prarthana²^ORCID,Stubbs Andrew³^ORCID,Dugar Gaurav⁴^ORCID,Hoogstrate Youri³,Kremers Gert-Jan⁵^ORCID,van Cappellen Wiggert A.⁵,Horst-Kreft Deborah¹,Laffeber Charlie⁶,Lebbink Joyce H.G.⁶⁷,Bruens Serena⁶,Gaskin Duncan⁸,Beerens Dior¹,Klunder Maarten²,Joosten Rob²,Demmers Jeroen A. A.⁹^ORCID,van Gent Dik⁶^ORCID,Mouton Johan W.¹,van der Spek Peter J.³^ORCID,van der Oost John²^ORCID,van Baarlen Peter¹⁰^ORCID,Louwen Rogier¹^ORCID

Affiliation:

1. Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

2. Laboratory of Microbiology, Wageningen University, Wageningen, Netherlands.

3. Clinical Bioinformatics, Department of Pathology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

4. Institute of Molecular Infection Biology (IMIB)/Research Center for Infectious Diseases (ZINF), University of Würzburg, Würzburg, Germany.

5. Optical Imaging Center, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

6. Department of Molecular Genetics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

7. Department of Radiation Oncology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

8. Institute of Food Research, Gut Health and Food Safety Programme, Norwich Research Park, Norwich, UK.

9. Proteomics Center, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

10. Host-Microbe Interactomics Group, University of Wageningen, Wageningen, Netherlands.

Abstract

CjeCas9 causes DNA damage in human cells.

Funder

Netherlands Organization of Scientific Research

LSH-TKI foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference52 articles.

1. Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems

2. CRISPR–Cas systems: beyond adaptive immunity

3. The Role of CRISPR-Cas Systems in Virulence of Pathogenic Bacteria

4. A Guild of 45 CRISPR-Associated (Cas) Protein Families and Multiple CRISPR/Cas Subtypes Exist in Prokaryotic Genomes

5. A novel link between Campylobacter jejuni bacteriophage defence, virulence and Guillain–Barré syndrome

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