Guide-free Cas9 from pathogenic Campylobacter jejuni bacteria causes severe damage to DNA

Author:

Saha Chinmoy1ORCID,Mohanraju Prarthana2ORCID,Stubbs Andrew3ORCID,Dugar Gaurav4ORCID,Hoogstrate Youri3,Kremers Gert-Jan5ORCID,van Cappellen Wiggert A.5,Horst-Kreft Deborah1,Laffeber Charlie6,Lebbink Joyce H.G.67,Bruens Serena6,Gaskin Duncan8,Beerens Dior1,Klunder Maarten2,Joosten Rob2,Demmers Jeroen A. A.9ORCID,van Gent Dik6ORCID,Mouton Johan W.1,van der Spek Peter J.3ORCID,van der Oost John2ORCID,van Baarlen Peter10ORCID,Louwen Rogier1ORCID

Affiliation:

1. Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

2. Laboratory of Microbiology, Wageningen University, Wageningen, Netherlands.

3. Clinical Bioinformatics, Department of Pathology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

4. Institute of Molecular Infection Biology (IMIB)/Research Center for Infectious Diseases (ZINF), University of Würzburg, Würzburg, Germany.

5. Optical Imaging Center, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

6. Department of Molecular Genetics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

7. Department of Radiation Oncology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

8. Institute of Food Research, Gut Health and Food Safety Programme, Norwich Research Park, Norwich, UK.

9. Proteomics Center, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

10. Host-Microbe Interactomics Group, University of Wageningen, Wageningen, Netherlands.

Abstract

CjeCas9 causes DNA damage in human cells.

Funder

Netherlands Organization of Scientific Research

LSH-TKI foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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