TREM-2 is a sensor and activator of T cell response in SARS-CoV-2 infection

Author:

Wu Yongjian12345ORCID,Wang Manni12ORCID,Yin Huan12ORCID,Ming Siqi126ORCID,Li Xingyu12ORCID,Jiang Guanmin7,Liu Ye12ORCID,Wang Peihui8ORCID,Zhou Guangde6ORCID,Liu Lei6ORCID,Gong Sitang4ORCID,Zhou Haibo5,Shan Hong123ORCID,Huang Xi12345ORCID

Affiliation:

1. Center for Infection and Immunity, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China.

2. Guangdong Provincial Engineering Research Center of Molecular Imaging, Guangdong Provincial Key Laboratory of Biomedical Imaging, and Department of Interventional Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China.

3. Southern Marine Science and Engineering Guangdong Laboratory, Zhuhai, Guangdong Province 519000, China.

4. Department of Gastroenterology, Guangzhou Women and Children’s Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, Guangzhou, Guangdong Province 510623, China.

5. The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, Qingyuan, Guangdong Province 511518, China.

6. National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong Province 518112, China.

7. Department of Clinical Laboratory, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China.

8. Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province 250012, China.

Abstract

TREM-2 recognizes SARS-CoV-2 membrane protein and activates CD3ζ/ZAP70/STAT1 signal pathway to induce antiviral T H 1 response.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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