Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality-Reference-Cited by-同舟云学术

Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality

Published:2020-11-20 Issue:47 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Demarco Benjamin¹^ORCID,Grayczyk James P.²^ORCID,Bjanes Elisabet²,Le Roy Didier³^ORCID,Tonnus Wulf⁴^ORCID,Assenmacher Charles-Antoine²^ORCID,Radaelli Enrico²^ORCID,Fettrelet Timothée¹^ORCID,Mack Vanessa¹^ORCID,Linkermann Andreas⁴^ORCID,Roger Thierry³^ORCID,Brodsky Igor E.²⁵^ORCID,Chen Kaiwen W.¹^ORCID,Broz Petr¹^ORCID

Affiliation:

1. Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.

2. Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA.

3. Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Epalinges, Switzerland.

4. Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.

5. Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Abstract

Caspase-8–dependent GSDMD activation promotes antibacterial defense; however, this pathway can also mediate TNF shock in vivo.

Funder

National Institutes of Health

Burroughs Wellcome Fund

H2020 European Research Council

H2020 Marie Skłodowska-Curie Actions

Deutsche Forschungsgemeinschaft

Swiss National Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)