A neural substrate of compulsive alcohol use

Author:

Domi Esi1ORCID,Xu Li12ORCID,Toivainen Sanne1,Nordeman Anton1,Gobbo Francesco3ORCID,Venniro Marco4,Shaham Yavin5,Messing Robert O.6ORCID,Visser Esther7ORCID,van den Oever Michel C.7ORCID,Holm Lovisa1ORCID,Barbier Estelle1ORCID,Augier Eric1ORCID,Heilig Markus1ORCID

Affiliation:

1. Center for Social and Affective Neuroscience, BKV, Linköping University, Linköping 581 85, Sweden.

2. Psychosomatic Medicine Center, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China.

3. Centre for Discovery Brain Sciences, University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK.

4. Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

5. Behavioral Neuroscience Branch Intramural Research Program, National Institute on Drug Abuse (NIDA), NIH, Baltimore, MD 21224, USA.

6. Waggoner Center for Alcohol and Addiction Research and Departments of Neuroscience and Neurology, University of Texas at Austin, Austin, TX 78712, USA.

7. Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, Netherlands.

Abstract

Inhibitory PKCδ-expressing neurons in the central nucleus of the amygdala promote compulsive alcohol use in rats.

Funder

Office of Enterprise Assessments

Vetenskapsrådet

Swedish Research Council for Health, Working Life and Welfare

Marianne and Marcus Wallenberg Foundation

Lions Research Funding

Intramural Research Program, NIDA-NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference74 articles.

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4. Evidence for Addiction-like Behavior in the Rat

5. A molecular mechanism for choosing alcohol over an alternative reward

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