Gelation of highly entangled hydrophobic macromolecular fluid for ultrastrong underwater in situ fast tissue adhesion

Author:

Liu Yuqing1ORCID,Guan Ge2ORCID,Li Yinghao23ORCID,Tan Ju2,Cheng Panke4,Yang Mingcan2,Li Bingyun5ORCID,Wang Quan6ORCID,Zhong Wen7ORCID,Mequanint Kibret89ORCID,Zhu Chuhong210ORCID,Xing Malcolm1ORCID

Affiliation:

1. Department of Mechanical Engineering, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.

2. Department of Anatomy, Key Laboratory for Biomechanics and Tissue Engineering of Chongqing Army Medical University (Third Military Medical University), Chongqing 400038, China.

3. Chongqing Institute of Zhong Zhi Yi Gu, Shapingba District, Chongqing 400030, China.

4. Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 611731, China.

5. Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, WV 26506, USA.

6. School of Civil Engineering, Shantou University, Shantou 515063, China.

7. Department of Biosystems Engineering, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.

8. Department of Chemical and Biochemical Engineering, University of Western Ontario, London, Ontario N6A 5B9, Canada.

9. School of Biomedical Engineering, University of Western Ontario, London, Ontario N6A 5B9, Canada.

10. State Key Laboratory of Trauma, Burn and Combined Injury, Department of Plastic and Aesthetic Surgery, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China.

Abstract

Although strong underwater bioadhesion is important for many biomedical applications, designing adhesives to perform in the presence of body fluids proves to be a challenge. To address this, we propose an underwater and in situ applicable hydrophobic adhesive (UIHA) composed of polydimethylsiloxane, entangled macromolecular silicone fluid, and a reactive silane. The hydrophobic fluid displaced the boundary water, formed an in situ gel, bonded to tissues, and achieved exceptional underwater adhesion strength. Its underwater lap shear adhesion on porcine skin was significantly higher than that of cyanoacrylate and fibrin glues, demonstrating excellent water resistance. The burst pressure of UIHA on porcine skin was 10 times higher than that of fibrin glue. The cytocompatible UIHA successfully sealed ruptured arteries, skin, and lungs in rats, pigs, rabbits, and dogs. Together, the gelation of highly entangled hydrophobic macromolecular fluid provided a means to prepare underwater bioadhesives with strong bonding to tissues and excellent water resistance.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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