Albumin-chaperoned cyanine dye yields superbright NIR-II fluorophore with enhanced pharmacokinetics

Author:

Tian Rui1ORCID,Zeng Qiao2ORCID,Zhu Shoujun1ORCID,Lau Joseph1,Chandra Swati1,Ertsey Robert3,Hettie Kenneth S.3ORCID,Teraphongphom Tarn3ORCID,Hu Zhubin4ORCID,Niu Gang1,Kiesewetter Dale O.1ORCID,Sun Haitao4ORCID,Zhang Xiaodong5ORCID,Antaris Alexander L.6,Brooks Bernard R.2ORCID,Chen Xiaoyuan1ORCID

Affiliation:

1. Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, MD 20892, USA.

2. Laboratory of Computational Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

3. Department of Otolaryngology, Stanford University, Stanford, CA 94305, USA.

4. State Key Laboratory of Precision Spectroscopy, School of Physics and Materials Science, East China Normal University, Shanghai 200062, P. R. China.

5. Department of Physics, School of Science, Tianjin University, Tianjin 300354, P. R. China.

6. Intuitive Surgical, Kifer Rd., Sunnyvale, CA 94086, USA.

Abstract

Complexation of cyanine dye with albumin produces efficient NIR-II fluorophore improving the resolution of in vivo bioimaging.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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