CDK13 cooperates with CDK12 to control global RNA polymerase II processivity

Author:

Fan Zheng12ORCID,Devlin Jennifer R.12ORCID,Hogg Simon J.1ORCID,Doyle Maria A.12,Harrison Paul F.34ORCID,Todorovski Izabela12,Cluse Leonie A.1ORCID,Knight Deborah A.1ORCID,Sandow Jarrod J.56,Gregory Gareth1ORCID,Fox Andrew1ORCID,Beilharz Traude H.3,Kwiatkowski Nicholas78ORCID,Scott Nichollas E.9ORCID,Vidakovic Ana Tufegdzic10,Kelly Gavin P.11ORCID,Svejstrup Jesper Q.10ORCID,Geyer Matthias12ORCID,Gray Nathanael S.78ORCID,Vervoort Stephin J.12ORCID,Johnstone Ricky W.12ORCID

Affiliation:

1. The Peter MacCallum Cancer Centre, Melbourne, 3000 VIC, Australia.

2. The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, 3052 VIC, Australia.

3. Monash Biomedicine Discovery Institute, Monash University, Clayton, 3800 VIC, Australia.

4. Monash Bioinformatics Platform, Monash University, Clayton, 3800 VIC, Australia.

5. Walter and Eliza Hall Institute of Medical Research, Parkville, 3052 VIC, Australia.

6. Department of Medical Biology, University of Melbourne, Melbourne, 3052 VIC, Australia.

7. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.

8. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

9. Department of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne, Parkville, 3052 VIC, Australia.

10. Mechanisms of Transcription Laboratory, The Francis Crick Institute, London NW1 1AT, UK.

11. Bioinformatics and Biostatistics, The Francis Crick Institute, London NW1 1AT, UK.

12. Institute of Structural Biology, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany.

Abstract

CDK12 and CDK13 regulate POLII elongation rate and processivity and influence the selection of transcription termination sites.

Funder

Victorian Cancer Agency

National Health and Medical Research Council

Cancer Council Victoria

The Kids Cancer Project

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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