MHC class I in dopaminergic neurons suppresses relapse to reward seeking

Author:

Murakami Gen123ORCID,Edamura Mitsuhiro1,Furukawa Tomonori4ORCID,Kawasaki Hideya2,Kosugi Isao2ORCID,Fukuda Atsuo4ORCID,Iwashita Toshihide2ORCID,Nakahara Daiichiro15ORCID

Affiliation:

1. Department of Psychology and Behavioral Neuroscience, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, Japan.

2. Department of Regenerative and Infectious Pathology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, Japan.

3. Department of Liberal Arts, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan.

4. Department of Neurophysiology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, Japan.

5. Department of Psychiatry, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, Japan.

Abstract

Cocaine self-administration persistently reduces MHCI in dopamine neurons, resulting in relapse to cocaine seeking.

Funder

Japan Society for the Promotion of Science

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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