Massive clonal expansion of polycytotoxic skin and blood CD8 + T cells in patients with toxic epidermal necrolysis

Author:

Villani Axel Patrice12ORCID,Rozieres Aurore1ORCID,Bensaid Benoît2,Eriksson Klara Kristin3ORCID,Mosnier Amandine1ORCID,Albert Floriane1,Mutez Virginie1,Brassard Océane1,Baysal Tugba1,Tardieu Mathilde1,Allatif Omran1ORCID,Fusil Floriane1,Andrieu Thibault14ORCID,Jullien Denis12ORCID,Dubois Valérie5ORCID,Giannoli Catherine5,Gruffat Henri1ORCID,Pallardy Marc6,Cosset François-Loïc1,Nosbaum Audrey17,Kanagawa Osami1ORCID,Maryanski Janet L.8,Yerly Daniel39ORCID,Nicolas Jean-François17ORCID,Vocanson Marc1

Affiliation:

1. Centre International de Recherche en Infectiologie (CIRI); INSERM, U1111; Université de Lyon 1; Ecole Normale Supérieure de Lyon; and CNRS, UMR 5308, Lyon, France.

2. Drug Allergy Reference Center, Hospices Civils de Lyon, Hôpital Edouard Herriot, Service de Dermatologie, Lyon, France.

3. Department of Rheumatology, Immunology and Allergology, Drug Allergy Research Laboratory, University Hospital of Bern, 3010 Bern, Switzerland.

4. SFR Biosciences Gerland, US8, UMS3444, Lyon, France.

5. Etablissement Français du Sang (EFS), Décines, France.

6. INSERM, UMR 996, Châtenay-Mallabry, France.

7. Département d’Allergologie et d’immunologie Clinique, Hôpital Lyon Sud, Pierre-Bénite, France.

8. Unité de Thérapie Cellulaire et Génique (UTCG), Centre Hospitalier Universitaire de Nice, 06101 Nice, France.

9. ADR-AC GmbH, Holligenstrasse 91, 3008 Bern, Switzerland.

Abstract

This study highlights the key role of polycytotoxic CD8 + T cells in the severity of toxic epidermal necrolysis.

Funder

French National Research Agency

French Society of Dermatology

French Society of Allergology

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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