Self-targeting, zwitterionic micellar dispersants enhance antibiotic killing of infectious biofilms—An intravital imaging study in mice-Reference-Cited by-同舟云学术

Self-targeting, zwitterionic micellar dispersants enhance antibiotic killing of infectious biofilms—An intravital imaging study in mice

Published:2020-08-14 Issue:33 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Tian Shuang¹²^ORCID,Su Linzhu¹²^ORCID,Liu Yong¹²^ORCID,Cao Jingjing¹,Yang Guang¹²,Ren Yijin³^ORCID,Huang Fan⁴^ORCID,Liu Jianfeng⁴^ORCID,An Yingli¹^ORCID,van der Mei Henny C.²^ORCID,Busscher Henk J.²^ORCID,Shi Linqi¹^ORCID

Affiliation:

1. State Key Laboratory of Medicinal Chemical Biology; Key Laboratory of Functional Polymer Materials, Ministry of Education; and Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P.R. China.

2. University of Groningen and University Medical Center Groningen, Department of Biomedical Engineering, Antonius Deusinglaan 1, 9713 AV Groningen, Netherlands.

3. University of Groningen and University Medical Center Groningen, Department of Orthodontics, Hanzeplein 1, 9700 RB Groningen, Netherlands.

4. Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, P.R. China.

Abstract

Zwitterionic micelles find their own path through the body to disperse an infectious biofilm and enhance antibiotic efficacy.

Funder

National Natural Science Foundation of China

CAMS Innovation Fund for Medical Sciences

Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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