Self-targeting, zwitterionic micellar dispersants enhance antibiotic killing of infectious biofilms—An intravital imaging study in mice

Author:

Tian Shuang12ORCID,Su Linzhu12ORCID,Liu Yong12ORCID,Cao Jingjing1,Yang Guang12,Ren Yijin3ORCID,Huang Fan4ORCID,Liu Jianfeng4ORCID,An Yingli1ORCID,van der Mei Henny C.2ORCID,Busscher Henk J.2ORCID,Shi Linqi1ORCID

Affiliation:

1. State Key Laboratory of Medicinal Chemical Biology; Key Laboratory of Functional Polymer Materials, Ministry of Education; and Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P.R. China.

2. University of Groningen and University Medical Center Groningen, Department of Biomedical Engineering, Antonius Deusinglaan 1, 9713 AV Groningen, Netherlands.

3. University of Groningen and University Medical Center Groningen, Department of Orthodontics, Hanzeplein 1, 9700 RB Groningen, Netherlands.

4. Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, P.R. China.

Abstract

Zwitterionic micelles find their own path through the body to disperse an infectious biofilm and enhance antibiotic efficacy.

Funder

National Natural Science Foundation of China

CAMS Innovation Fund for Medical Sciences

Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference60 articles.

1. Nanotechnology-based antimicrobials and delivery systems for biofilm-infection control

2. Understanding biofilm resistance to antibacterial agents

3. J. O’Neill Antimicrobial resistance: Tackling a crisis for the health and wealth of nations. Review on antimicrobial resistance (Creative Commons Attribution 4.0 International Public Licence 2014).

4. “Nanoantibiotics”: A new paradigm for treating infectious diseases using nanomaterials in the antibiotics resistant era

5. Antimicrobial Resistance: A Global Challenge

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