Long-lasting forms of plasticity through patterned ultrasound-induced brainwave entrainment

Author:

Kim Ho-Jeong12ORCID,Phan Tien Thuy13ORCID,Lee Keunhyung45ORCID,Kim Jeong Sook6ORCID,Lee Sang-Yeong13ORCID,Lee Jung Moo1ORCID,Do Jongrok17ORCID,Lee Doyun1ORCID,Kim Sung-Phil2ORCID,Lee Kyu Pil6ORCID,Park Jinhyoung455ORCID,Lee C. Justin123ORCID,Park Joo Min123ORCID

Affiliation:

1. Center for Cognition and Sociality, Institute for Basic Science, Daejeon, Republic of Korea.

2. Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea.

3. University of Science and Technology (UST), Daejeon, Republic of Korea.

4. Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Republic of Korea.

5. Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea.

6. Department of Physiology, College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea.

7. Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.

Abstract

Achieving long-lasting neuronal modulation with low-intensity, low-frequency ultrasound is challenging. Here, we devised theta burst ultrasound stimulation (TBUS) with gamma bursts for brain entrainment and modulation of neuronal plasticity in the mouse motor cortex. We demonstrate that two types of TBUS, intermittent and continuous TBUS, induce bidirectional long-term potentiation or depression-like plasticity, respectively, as evidenced by changes in motor-evoked potentials. These effects depended on molecular pathways associated with long-term plasticity, including N -methyl- d -aspartate receptor and brain-derived neurotrophic factor/tropomyosin receptor kinase B activation, as well as de novo protein synthesis. Notably, bestrophin-1 and transient receptor potential ankyrin 1 play important roles in these enduring effects. Moreover, pretraining TBUS enhances the acquisition of previously unidentified motor skills. Our study unveils a promising protocol for ultrasound neuromodulation, enabling noninvasive and sustained modulation of brain function.

Publisher

American Association for the Advancement of Science (AAAS)

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