Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells-Reference-Cited by-同舟云学术

Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells

Published:2021-12-24 Issue:52 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Sun Yan¹^ORCID,Lin Xiaolin²^ORCID,Liu Bangdong¹,Zhang Yaxuan²,Li Wei¹,Zhang Sheng³^ORCID,He Falian¹^ORCID,Tian Han¹^ORCID,Zhu Xun¹,Liu Ximeng¹^ORCID,Wu Jueheng¹,Cai Junchao¹^ORCID,Li Mengfeng¹²^ORCID

Affiliation:

1. Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.

2. Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.

3. Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China.

Abstract

Loss of ATF4 intrinsically leads to functional aging-like attrition of adult hematopoietic stem cells via targeting HIF1α.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference59 articles.

1. Cellular Senescence: Aging, Cancer, and Injury

2. Hallmarks of Cellular Senescence

3. Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases

4. The Hallmarks of Aging

5. Aging of hematopoietic stem cells

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