Sex-dependent regulation of vertebrate somatic growth and aging by germ cells-Reference-Cited by-同舟云学术

Sex-dependent regulation of vertebrate somatic growth and aging by germ cells

Published:2024-06-14 Issue:24 Volume:10 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Abe Kota¹^ORCID,Ino Hikaru¹,Niwa Tomomi¹,Semmy Daniel¹,Takaochi Ayami¹,Nishimura Takashi²^ORCID,Mogi Chihiro³^ORCID,Uenaka Maki⁴⁵^ORCID,Ishii Masaru⁴⁵⁶^ORCID,Tanaka Kaori⁷,Ohkawa Yasuyuki⁷^ORCID,Ishitani Tohru¹⁶^ORCID

Affiliation:

1. Department of Homeostatic Regulation, Division of Cellular and Molecular Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.

2. Metabolic Regulation and Genetics, Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.

3. Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.

4. Department of Immunology and Cell Biology, Graduate School of Medicine / Graduate School of Frontier Biosciences, Osaka University, Suita, Japan.

5. Immunology Frontier Research Center, Osaka University, Suita, Japan.

6. Center for Infectious Disease Education and Research (CiDER), Osaka University, Suita, Japan.

7. Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.

Abstract

The function of germ cells in somatic growth and aging has been demonstrated in invertebrate models but remains unclear in vertebrates. We demonstrated sex-dependent somatic regulation by germ cells in the short-lived vertebrate model Nothobranchius furzeri . In females, germ cell removal shortened life span, decreased estrogen, and increased insulin-like growth factor 1 (IGF-1) signaling. In contrast, germ cell removal in males improved their health with increased vitamin D signaling. Body size increased in both sexes but was caused by different signaling pathways, i.e., IGF-1 and vitamin D in females and males, respectively. Thus, vertebrate germ cells regulate somatic growth and aging through different pathways of the endocrine system, depending on the sex, which may underlie the sexual difference in reproductive strategies.

Publisher

American Association for the Advancement of Science (AAAS)

Link

https://www.science.org/doi/pdf/10.1126/sciadv.adi1621

Reference54 articles.

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