Platelets trigger perivascular mast cell degranulation to cause inflammatory responses and tissue injury

Author:

Karhausen Jörn1ORCID,Choi Hae Woong23ORCID,Maddipati Krishna Rao4ORCID,Mathew Joseph P.1,Ma Qing1,Boulaftali Yacine5,Lee Robert Hugh6ORCID,Bergmeier Wolfgang67ORCID,Abraham Soman N.28910ORCID

Affiliation:

1. Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA.

2. Department of Pathology, Duke University Medical Center, Durham, NC, USA.

3. Department of Life Sciences, Korea University, Seoul 02841, South Korea.

4. Department of Pathology, Wayne State University, Detroit, MI, USA.

5. Université Paris Diderot, Sorbonne Paris Cité, Laboratory of Vascular Translational Science, U1148 Institute National de la Santé et de la Recherche Medicale (INSERM), Paris, France.

6. Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, USA.

7. UNC Center for Blood Research, University of North Carolina, Chapel Hill, NC, USA.

8. Department of Immunology, Duke University Medical Center, Durham, NC, USA.

9. Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.

10. Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore, Singapore.

Abstract

Activated platelets cause microvascular inflammation via direct activation of perivascular mast cells.

Funder

National Institutes of Health

National Heart, Lung, and Blood Institute

National Heart and Lung Institute

Duke clinical and translational science institute

American Heart Association

National Center for Research Resources

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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