Aneuploidy and a deregulated DNA damage response suggest haploinsufficiency in breast tissues of BRCA2 mutation carriers-Reference-Cited by-同舟云学术

Aneuploidy and a deregulated DNA damage response suggest haploinsufficiency in breast tissues of BRCA2 mutation carriers

Published:2020-01-31 Issue:5 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Karaayvaz-Yildirim Mihriban¹^ORCID,Silberman Rebecca E.²^ORCID,Langenbucher Adam¹,Saladi Srinivas Vinod¹³⁴^ORCID,Ross Kenneth N.¹⁴^ORCID,Zarcaro Elena¹,Desmond Andrea¹,Yildirim Murat⁵^ORCID,Vivekanandan Varunika¹,Ravichandran Hiranmayi⁶,Mylavagnanam Ravindra⁶^ORCID,Specht Michelle C.⁷,Ramaswamy Sridhar¹⁴,Lawrence Michael¹⁴⁶^ORCID,Amon Angelika²^ORCID,Ellisen Leif W.¹^ORCID

Affiliation:

1. Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

2. Koch Institute for Integrative Cancer Research, Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

3. Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA.

4. Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

5. Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

6. Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

7. Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.

Abstract

Normal breast epithelia from BRCA2 mutation carriers display DNA damage and attenuated checkpoint responses.

Funder

Howard Hughes Medical Institute

Susan G. Komen for the Cure

Terri Brodeur Breast Cancer Foundation

DOD Peer Reviewed Cancer Research Program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference43 articles.

1. HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

2. Two Decades After BRCA: Setting Paradigms in Personalized Cancer Care and Prevention

3. Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.

4. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

5. Brca2 is required for embryonic cellular proliferation in the mouse.

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