Osteoprotegerin reduces osteoclast resorption activity without affecting osteogenesis on nanoparticulate mineralized collagen scaffolds

Author:

Ren Xiaoyan123ORCID,Zhou Qi123,Foulad David123,Tiffany Aleczandria S.4ORCID,Dewey Marley J.5ORCID,Bischoff David2ORCID,Miller Timothy A.12,Reid Russell R.6ORCID,He Tong-Chuan7,Yamaguchi Dean T.2,Harley Brendan A. C.48ORCID,Lee Justine C.123ORCID

Affiliation:

1. Division of Plastic and Reconstructive Surgery, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA.

2. Research Service, Greater Los Angeles VA Healthcare System, Los Angeles, CA 90073, USA.

3. UCLA Molecular Biology Institute, Los Angeles, CA 90095, USA.

4. Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

5. Department of Materials Science and Engineering, Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

6. Section of Plastic and Reconstructive Surgery, University of Chicago, Chicago, IL 60637, USA.

7. Department of Orthopaedic Surgery, University of Chicago, Chicago, IL 60637, USA.

8. Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

Abstract

Osteoprotegerin reduces osteoclast resorption activity without affecting osteogenesis on nanoparticulate mineralized collagen.

Funder

National Institute of Dental and Craniofacial Research

Plastic Surgery Foundation

Office of the Assistant Secretary for Health

Jean Perkins Foundation

AO Foundation

NSF Graduate Research Fellowship

United States Department of Veterans Affairs

Aramont Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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