A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds-Reference-Cited by-同舟云学术

A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds

Published:2018-08-03 Issue:8 Volume:4 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Song Haigang¹²^ORCID,van der Velden Niels S.³,Shiran Sally L.¹^ORCID,Bleiziffer Patrick⁴,Zach Christina³,Sieber Ramon³,Imani Aman S.⁵,Krausbeck Florian⁴,Aebi Markus³^ORCID,Freeman Michael F.⁵^ORCID,Riniker Sereina⁴^ORCID,Künzler Markus³^ORCID,Naismith James H.²⁶⁷^ORCID

Affiliation:

1. Biomedical Sciences Research Complex, North Haugh, University of St. Andrews, Fife KY16 9ST, UK.

2. Division of Structural Biology, Wellcome Trust Centre of Human Genomics, Roosevelt Drive, Oxford OX3 7BN, UK.

3. Institute of Microbiology, Department of Biology, Eidgenössische Technische Hochschule (ETH) Zürich, Zürich, Switzerland.

4. Laboratory of Physical Chemistry, Department of Chemistry and Applied Biosciences, Eidgenössische Technische Hochschule (ETH) Zürich, Zürich, Switzerland.

5. Department of Biochemistry, Molecular Biology, and Biophysics, and BioTechnology Institute, University of Minnesota–Twin Cities, St. Paul, MN 55108, USA.

6. State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China.

7. Research Complex at Harwell, Rutherford Laboratory, Didcot, Oxfordshire OX11 0FA, UK.

Abstract

We report the structure of a fungal enzyme that activates the amide bond, allowing nucleophilic chemistry.

Funder

Wellcome Trust

H2020 European Research Council

Biotechnology and Biological Sciences Research Council

Swiss National Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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