Rapid and inefficient kinetics of sickle hemoglobin fiber growth

Author:

Castle Brian T.1ORCID,Odde David J.1ORCID,Wood David K.1ORCID

Affiliation:

1. Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.

Abstract

Nanoscale analysis reveals the rapid and inefficient sickle hemoglobin self-assembly process.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference39 articles.

1. Three-dimensional reconstruction of the 14-filament fibers of hemoglobin S;Dykes G. W.;J. Mol. Biol.,1979

2. Three-dimensional reconstruction of the fibres of sickle cell haemoglobin;Dykes G.;Nature,1978

3. Pathogenesis and treatment of sickle cell disease;Bunn H. F.;N. Engl. J. Med.,1997

4. F. Oosawa S. Asakura Thermodynamics of the Polymerization of Protein (Academic Press 1975).

5. Dynamic instability of microtubule growth

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