Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis-Reference-Cited by-同舟云学术

Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis

Published:2020-08-21 Issue:34 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Verma Nandini¹^ORCID,Vinik Yaron¹^ORCID,Saroha Ashish¹^ORCID,Nair Nishanth Ulhas²^ORCID,Ruppin Eytan²^ORCID,Mills Gordon³^ORCID,Karn Thomas⁴^ORCID,Dubey Vinay¹^ORCID,Khera Lohit¹,Raj Harsha¹^ORCID,Maina Flavio⁵^ORCID,Lev Sima¹^ORCID

Affiliation:

1. Molecular Cell Biology Department, Weizmann Institute of Science, Rehovot 20892, Israel.

2. Cancer Data Science Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

3. Knight Cancer Institute, Portland, OR 97201, USA.

4. Department of Obstetrics and Gynecology, Goethe University, D-60323 Frankfurt, Germany.

5. Aix Marseille Univ, CNRS, Developmental Biology Institute of Marseille (IBDM) UMR 7288, Marseille, France.

Abstract

Synthetic lethal combination induces ferroptosis.

Funder

Israel Science Foundation

ISF-NSFC joint research program

MDACC-SINF

David E. Stone

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference59 articles.

1. Targeted Therapies for Triple-Negative Breast Cancer: Combating a Stubborn Disease

2. Molecular Stratification of Triple-Negative Breast Cancers

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4. Exploiting synthetic lethality to improve cancer therapy

5. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

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