Distinct phosphorylation sites in a prototypical GPCR differently orchestrate β-arrestin interaction, trafficking, and signaling-Reference-Cited by-同舟云学术

Distinct phosphorylation sites in a prototypical GPCR differently orchestrate β-arrestin interaction, trafficking, and signaling

Published:2020-09-11 Issue:37 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Dwivedi-Agnihotri Hemlata¹^ORCID,Chaturvedi Madhu¹^ORCID,Baidya Mithu¹^ORCID,Stepniewski Tomasz Maciej²³,Pandey Shubhi¹^ORCID,Maharana Jagannath¹,Srivastava Ashish¹^ORCID,Caengprasath Natarin⁴,Hanyaloglu Aylin C.⁴^ORCID,Selent Jana²^ORCID,Shukla Arun K.¹^ORCID

Affiliation:

1. Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.

2. Research Programme on Biomedical Informatics (GRIB), Department of Experimental and Health Sciences of Pompeu Fabra University (UPF)-Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain.

3. Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, Warsaw, Poland.

4. Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Hammersmith Campus, Imperial College London, Du Cane Road, London, W12 0NN, UK.

Abstract

GPCR–β-arrestin interaction and signaling are differentially regulated by distinct phosphorylation sites on the receptor.

Funder

Department of Biotechnology , Ministry of Science and Technology

Department of Science and Technology, Ministry of Science and Technology

Council of Scientific and Industrial Research

Science and Engineering Research Board

DBT India Alliance

Instituto de Salud Carlos III

Publisher

American Association for the Advancement of Science (AAAS)

Subject