Ectopic expression of Irx3 and Irx5 in the paraventricular nucleus of the hypothalamus contributes to defects in Sim1 haploinsufficiency-Reference-Cited by-同舟云学术

Ectopic expression of Irx3 and Irx5 in the paraventricular nucleus of the hypothalamus contributes to defects in Sim1 haploinsufficiency

Published:2021-10-29 Issue:44 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Son Joe Eun¹^ORCID,Dou Zhengchao¹²^ORCID,Wanggou Siyi¹³⁴,Chan Jade¹²,Mo Rong¹,Li Xuejun³⁴^ORCID,Huang Xi¹²^ORCID,Kim Kyoung-Han¹^ORCID,Michaud Jacques L.⁵⁶^ORCID,Hui Chi-chung¹²^ORCID

Affiliation:

1. Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.

2. Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.

3. Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

4. Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

5. CHU Sainte-Justine Research Center, Montreal, QC H3T 1C5, Canada.

6. Departments of Pediatrics and Neurosciences, Université de Montréal, Montreal, QC H3T 1J4, Canada.

Abstract

Irx3 and Irx5 misexpression in paraventricular nucleus of the hypothalamus leads to hyperphagic obesity in Sim1 haploinsufficiency.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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