Ultradeep sequencing differentiates patterns of skin clonal mutations associated with sun-exposure status and skin cancer burden-Reference-Cited by-同舟云学术

Ultradeep sequencing differentiates patterns of skin clonal mutations associated with sun-exposure status and skin cancer burden

Published:2021-01 Issue:1 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Wei Lei¹^ORCID,Christensen Sean R.²^ORCID,Fitzgerald Megan E.³,Graham James¹,Hutson Nicholas D.¹^ORCID,Zhang Chi⁴,Huang Ziyun⁵,Hu Qiang¹^ORCID,Zhan Fenglin¹⁶,Xie Jun⁷,Zhang Jianmin⁸,Liu Song¹,Remenyik Eva⁹,Gellen Emese⁹^ORCID,Colegio Oscar R.¹⁰¹¹,Bax Michael¹⁰,Xu Jinhui¹²,Lin Haifan¹³,Huss Wendy J.¹⁴^ORCID,Foster Barbara A.¹⁴^ORCID,Paragh Gyorgy³¹⁰^ORCID

Affiliation:

1. Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

2. Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA.

3. Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

4. School of Biological Sciences Center for Plant Science and Innovation, University of Nebraska, Lincoln, NE, USA.

5. Department of Computer Science and Software Engineering, Penn State Erie, The Behrend College, Erie, PA, USA.

6. PET/CT Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui, P.R. China.

7. Department of Statistics, Purdue University, West Lafayette, IN, USA.

8. Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

9. Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

10. Department of Dermatology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

11. Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

12. Department of Computer Science and Engineering, State University of New York at Buffalo, Buffalo, NY, USA.

13. Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.

14. Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

Abstract

Specific patterns of DNA mutations in normal skin show history of UV exposure and association with cancer risk.

Funder

National Institutes of Health

National Cancer Institute

Dermatology Foundation

Roswell Park Alliance Foundation, Roswell Park Cancer Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference41 articles.

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2. Prevention and Early Detection Strategies for Melanoma and Skin Cancer

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4. UV Signature Mutations

5. Ultraviolet Radiation Induced Signature Mutations in Photocarcinogenesis

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