Bypassing mitochondrial complex III using alternative oxidase inhibits acute pulmonary oxygen sensing-Reference-Cited by-同舟云学术

Bypassing mitochondrial complex III using alternative oxidase inhibits acute pulmonary oxygen sensing

Published:2020-04-17 Issue:16 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Sommer Natascha¹^ORCID,Alebrahimdehkordi Nasim¹^ORCID,Pak Oleg¹,Knoepp Fenja¹,Strielkov Ievgen¹,Scheibe Susan¹,Dufour Eric²^ORCID,Andjelković Ana²^ORCID,Sydykov Akylbek¹^ORCID,Saraji Alireza¹^ORCID,Petrovic Aleksandar¹,Quanz Karin¹,Hecker Matthias¹,Kumar Manish¹,Wahl Joel³,Kraut Simone¹,Seeger Werner¹^ORCID,Schermuly Ralph T.¹^ORCID,Ghofrani Hossein A.¹⁴^ORCID,Ramser Kerstin³^ORCID,Braun Thomas⁵^ORCID,Jacobs Howard T.²,Weissmann Norbert¹^ORCID,Szibor Marten²^ORCID

Affiliation:

1. Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany.

2. Faculty of Medicine and Health Technology, Tampere University, FI-33014 Tampere, Finland.

3. Department of Engineering Sciences and Mathematics, Luleå University of Technology, SE-97187 Luleå, Sweden.

4. Department of Medicine, Imperial College London, Du Cane Road, Hammersmith Campus, London W12 0NN, UK.

5. Department I, Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, D-61231 Bad Nauheim, Germany.

Abstract

Signaling from the mitochondrial respiratory chain is essential for acute vascular oxygen sensing in the lung.

Funder

European Research Council

Deutsche Forschungsgemeinschaft

Swedish Research Council for Health, Working Life and Welfare

Academy of Finland

Sigrid Juselius Foundation

Tampere University Hospital Medical Research Fund

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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1. Oxygen sensing and signal transduction in hypoxic pulmonary vasoconstriction

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5. Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing

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