A quasi-paired cohort strategy reveals the impaired detoxifying function of microbes in the gut of autistic children-Reference-Cited by-全球学者库

A quasi-paired cohort strategy reveals the impaired detoxifying function of microbes in the gut of autistic children

Published:2020-10-23 Issue:43 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Zhang Mengxiang¹^ORCID,Chu Yanan²^ORCID,Meng Qingren³^ORCID,Ding Rui¹⁴,Shi Xing⁵^ORCID,Wang Zuqun¹⁴,He Yi¹⁴,Zhang Juan⁶,Liu Jing⁷,Zhang Jie⁸,Yu Jun²,Kang Yu²^ORCID,Wang Juan¹⁴^ORCID

Affiliation:

1. Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University, Beijing 100191, China.

2. CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing 100101, China.

3. School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China.

4. Autism Research Center of Peking University Health Science Center, Beijing 100191, China.

5. Department of Respiratory and Critical Care Medicine, Peking University People’s Hospital, Beijing 100044, China.

6. Department of Pediatrics, Peking University Third Hospital, Beijing 100191, China.

7. Key Laboratory of Mental Health, Ministry of Health, Peking University Institute of Mental Health, Peking University Sixth Hospital, Beijing 100191, China.

8. Children Health Care Center, Xi’an Children’s Hospital, Xi’an 710003, China.

Abstract

Impairment in gut microbial detoxification is correlated with mitochondrial dysfunction and disease severity in autistic children.

Funder

National Science and Technology Major Project of China

National Science Foundation of China

Programs of the Chinese Academy of Sciences

the Grant of Peking University Medical Sciences Center

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary