A chemical biology approach reveals a dependency of glioblastoma on biotin distribution

Author:

Yoon Jeehyun12ORCID,Grinchuk Oleg V.12ORCID,Kannan Srinivasaraghavan3,Ang Melgious Jin Yan45,Li Zhenglin4ORCID,Tay Emmy Xue Yun12ORCID,Lok Ker Zhing12ORCID,Lee Bernice Woon Li12ORCID,Chuah You Heng12,Chia Kimberly12,Tirado Magallanes Roberto6ORCID,Liu Chenfei4,Zhao Haonan4,Hor Jin Hui7,Lim Jhin Jieh6ORCID,Benoukraf Touati68ORCID,Toh Tan Boon910ORCID,Chow Edward Kai-Hua611,Kovalik Jean-Paul12,Ching Jianhong12ORCID,Ng Shi-Yan1713ORCID,Koh Ming Joo4ORCID,Liu Xiaogang4ORCID,Verma Chandra Shekhar31415ORCID,Ong Derrick Sek Tong12713ORCID

Affiliation:

1. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore.

2. NUS Center for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

3. Biomolecular Modeling and Design Division, Bioinformatics Institute, A*STAR (Agency for Science, Technology and Research), Singapore 138671, Singapore.

4. Department of Chemistry, National University of Singapore, Singapore 117543, Singapore.

5. NUS Graduate School for Integrative Sciences and Engineering (NGS), National University of Singapore, Singapore 119077, Singapore.

6. Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.

7. Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore , Singapore.

8. Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL A1B 3V6, Canada.

9. The N.1 Institute for Health, National University of Singapore, Singapore , Singapore.

10. Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

11. Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

12. Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore 169857, Singapore.

13. National Neuroscience Institute, Singapore 308433, Singapore.

14. Department of Biological Sciences, National University of Singapore, Singapore 117558, Singapore.

15. School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.

Abstract

An antifungal drug reveals a dependency of glioblastoma on intracellular biotin distribution.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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