Improving the efficiency of precise genome editing with site-specific Cas9-oligonucleotide conjugates-Reference-Cited by-同舟云学术

Improving the efficiency of precise genome editing with site-specific Cas9-oligonucleotide conjugates

Published:2020-04-10 Issue:15 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Ling Xinyu¹^ORCID,Xie Bingteng²³^ORCID,Gao Xiaoqin¹^ORCID,Chang Liying¹,Zheng Wei¹^ORCID,Chen Heqi¹,Huang Yujia¹^ORCID,Tan Linzhi¹,Li Mo²³^ORCID,Liu Tao¹^ORCID

Affiliation:

1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China.

2. Center for Reproductive Medicine, Peking University Third Hospital, 100191 Beijing, China.

3. Key Laboratory of Assisted Reproduction, Ministry of Education, 100191 Beijing, China.

Abstract

A chemical protein-DNA conjugation approach enhances precise genome editing in human cells and mouse zygotes.

Funder

National Natural Science Foundation of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference40 articles.

1. Selective chemical protein modification